How to Choose the Right Contraceptive Method
How They Work; Pros and Cons
Intra-uterine System (Mirena®)
| Composition |
A small polyethylene T-shaped frame. The stem of the T has a cylindrical reservoir that contains levonorgestrel. The cylinder slowly releases the hormone through a rate-limiting membrane. |
| Mechanism of Action | The IUS produces a weak foreign body reaction and endometrial changes that include endometrial decidualization and glandular atrophy. Cervical mucus may become thicker which creates a barrier to sperm penetration. Ovulation may be inhibited in some women. |
| Dosage |
The Mirena IUS is available in only one dosage of levonorgestrel. It is effective for up to five years. The IUS can be inserted at any time during the menstrual cycle once pregnancy or the possibility of pregnancy has been ruled out. Insertion may be easier at the time of menstruation, or 3-4 hours after the vaginal insertion of 400 mcg of misoprostol. It is effective immediately. |
| Advantages |
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| Disadvantages/Side Effects- |
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| Efficacy- | The Mirena IUS is an extremely effective method of contraception. The Pearl Index is 0.09 (number of failures per 100 women years of use). |
| Contraindications/Poor Candidates- |
Absolute
Relative
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| Follow-up | One to three months after insertion to review satisfaction, side effects, and to reinforce the issue of condom use for protection against STIs and HIV. The IUS user should be instructed to contact a health care provider if any of the following occur: she cannot feel the IUS threads; she or her partner can feel the lower end of the IUS; she thinks she is pregnant; she experiences persistent abdominal pain, fever or unusual vaginal discharge; she or her partner fell pain during intercourse; she wishes to have the device removed or she wishes to conceive. |
Last Modified: November 6, 2007